Progress in Multicomponent Reaction Strategies for the Synthesis of 2‐Amino‐5‐Oxo‐4‐Phenyl‐4H,5H‐Pyrano[3,2‐ c ][1]benzopyran‐3‐Carbonitrile Derivatives: A Recent Overview
Abstract
This review highlights recent advancements (2021-2025) in the one-pot multicomponent synthesis of 2-amino-5-oxo-4-phenyl-4H,5H-pyrano[3,2-c][1]benzopyran-3-carbonitriles, a class of biologically significant heterocycles with diverse pharmacological properties. The methodologies are categorized based on the type of catalyst used, including deep eutectic solvent-based catalysts, ionic liquid-based catalysts, nanocatalysts, heterogeneous hybrid solid green catalysts, homogeneous base catalysts like piperidine, agro-waste extract, organo-salt catalyst and tertiary base surfactant. These catalytic systems have demonstrated improvements in reaction efficiency, environmental sustainability, and product yields. By organizing these developments, the review provides a valuable resource for guiding future research in green and efficient heterocyclic synthesis.
Fields of Study & Subjects
Multicomponent Synthesis of Heterocycles
Synthesis of heterocyclic compounds
Synthesis and biological activity
Publication details
- Journal / source
- The Chemical Record
- Publisher
- Wiley
- Volume
- 26
- Issue
- 5
- Pages
- e202500305–e202500305
- Publication date
- 4 March 2026
- Language
- EN