Best of United European Gastroenterology Week 2025

IntroductionUEG Week 2025, held in Berlin, brought together over 12,200 participants from 115 countries, including more than 5200 postgraduate trainees, and showcased 4168 abstracts in Gastroenterology and Hepatology, spanning basic science to clinical practice.The week opened with an inspiring address by UEG President Prof.Dr. Mathias Löhr and Scientific Committee Chair Prof. Dr. Julia Mayerle, setting the tone for an engaging and exciting forum for the international community to exchange innovative ideas, research, and practice-changing clinical insights.A major novelty at UEG Week 2025 was the debut of the Digestive Disease Mechanism (DDM) Summit.This 3-day standalone program on gastrointestinal pathogenesis, including malignancies, highlighted the fundamental role of basic science in translational gastroenterology.The summit was exceptionally well-organized and drew outstanding interest from basic researchers around the world, providing a high-quality platform for scientific discussion.We are pleased to announce that the DDM Summit will take place again in Barcelona in 2026 alongside UEG Week.The purpose of this editorial is to share the key highlights and pivotal takeaways from UEG Week 2025 with the academic community.The authors have selected works based on their scientific impact, recognition by the scientific committee and their direct relevance to the clinical themes discussed in the following section.To achieve this clarity, we have structured this summary into distinct sections focusing on Oncology, Endoscopy, Inflammatory Bowel Diseases, Luminal and Neurogastroenterology and Motility, Pancreatology, and Hepatology.