Microwave‐assisted synthesis and evaluation of anti‐inflammatory activity of naphthoquinone derivatives containing a trifluoromethyl group

Vietnam Journal of Chemistry 2026 Open access

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Authors: Nguyễn Hà Thanh, Hoàng Thị Phương, Nguyen Tuan Anh, Nguyen Thi Thu Ha, Nguyen Thi Quynh Giang, Dang Thi, Le Thị Tu Anh, Vu Ngoc Doan, Le Nhat Thuy Giang, Dang Thi Tuyet Anh
DOI: 10.1002/vjch.70125
Cited by: 1
References: 35

Abstract

Abstract This study presents the evaluation of the anti‐inflammatory activity of twelve naphthoquinone compounds containing a trifluoromethyl group in lipopolysaccharide‐stimulated RAW 264.7 macrophage cells. All compounds effectively suppressed NO production with IC 50 ranging from 0.95 ± 0.04 to 13.81 ± 1.39 µM without exerting toxic effects. Notably, compound 9f , exhibiting the strongest NO inhibitory activity with an IC 50 value of 0.95 ± 0.04 µM, significantly reduced the levels of pro‐inflammatory cytokine (IL‐1β and IL‐6) in a concentration‐dependent manner. Besides that, the ADMET analyses suggested that compound 9f exhibited promising drug‐like properties with acceptable safety profiles. These findings reveal the importance of these compounds in the development of anti‐inflammatory agents.

Fields of Study & Subjects

Bioactive Compounds and Antitumor Agents Morinda citrifolia extract uses Microwave-Assisted Synthesis and Applications

Publication details

Journal / source
Vietnam Journal of Chemistry
Publisher
Wiley
Volume
64
Issue
4
Pages
620–628
Publication date
24 January 2026
Language
EN