Aspects of irreversibility analysis in the reactive dynamics of a peristaltic non‐Newtonian nanofluid inside an irregular vertical stream under convective conditions

Abstract This study presents a novel thermodynamic analysis of reactive peristaltic nanofluid flow within an irregular vertical conduit under convective conditions, emphasizing the behavior of a non‐Newtonian Casson nanofluid. The investigation integrates irreversibility analysis to explore entropy generation and energy dissipation mechanisms relevant to biomedical processes such as targeted drug delivery and hyperthermia therapy. The governing nonlinear partial differential equations were solved using MATHEMATICA‐13 software to evaluate the effects of key parameters on physiological quantities. Comparative analysis between Casson and Newtonian fluids reveals that the Casson model offers superior control over energy loss and heat transfer, making it more favorable for efficient thermal regulation in biomedical applications. The study further identifies the influence of flow parameters on trapping phenomena, providing insights into optimizing peristaltic transport for therapeutic fluid delivery.