Golgi Drivers of Cancer

Sub-cellular biochemistry/Subcellular biochemistry 2026 Book chapter Open access

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Authors: Kyle A. Starost, Jagadeeswara Rao Bommi, Prasenjit Mitra, Seth J. Field
DOI: 10.1007/978-3-032-16833-7_15
Cited by: 1
References: 223

Abstract

Unbiased analyses of cancer genomes, transcriptomes, and proteomes have led to the identification of numerous genes that, when perturbed, contribute to the formation of cancer in humans. These unbiased analyses, by identifying drivers of cancer that localize to and function at the Golgi, have illuminated a previously unappreciated role for the Golgi in driving oncogenic phenotypes. Here we review some of the cancer drivers that act at the Golgi. We highlight the evidence that they are functionally important in cancer, and the evidence that they localize to and function at the Golgi. We also discuss functional interactions between these proteins, and review some of the proposed mechanisms by which they promote oncogenic phenotypes.

Fields of Study & Subjects

Cellular transport and secretion Endoplasmic Reticulum Stress and Disease Microtubule and mitosis dynamics

Publication details

Journal / source
Sub-cellular biochemistry/Subcellular biochemistry
Publisher
Springer Nature Switzerland
Volume
111
Pages
351–380
Publication date
1 January 2026
Language
EN
Document type
Book chapter