Macrophage polarization in inflammatory regulation: molecular mechanisms, therapeutic targets, and translational challenges
Abstract
Macrophage polarization plays a vital role in regulating inflammation, and the balance of this process is crucial for maintaining tissue health and influencing disease progression. Recent studies have shown how macrophages can adapt their phenotypes in response to their surroundings, underscoring the importance of their polarization changes in various inflammatory conditions, such as infections, tumors, metabolic disorders, and autoimmune diseases. This review brings together significant advancements in our understanding of the signaling pathways involved in inflammation, the role of epigenetic factors, metabolic changes, and the development of targeted therapies, with the goal of offering new perspectives on treating inflammation-related diseases.
Fields of Study & Subjects
Immune cells in cancer
Immune responses and vaccinations
Phagocytosis and Immune Regulation
Publication details
- Journal / source
- Cellular and Molecular Life Sciences
- Publisher
- Springer Science and Business Media LLC
- Volume
- 83
- Issue
- 1
- Publication date
- 10 March 2026
- Language
- EN