Blood DNA methylation markers are associated with diabetic kidney disease progression in type 1 diabetes

Diabetologia 2026 Open access

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Authors: Anna Syreeni, Emma H. Dahlström, Laura J. Smyth, Claire Hill, Stefan Mutter, Valma Harjutsalo, Z. Chen, Rama Natarajan, Andrzej S. Krolewski, Joel N. Hirschhorn, J. C. Florez, Alexander P. Maxwell
+4 more Per-Henrik Groop, Amy Jayne McKnight, Niina Sandholm, the FinnDiane Study Group
DOI: 10.1007/s00125-025-06661-7
Cited by: 4
References: 64

Abstract

Abstract Aims/hypothesis DNA methylation has been shown to be associated with kidney function and diabetic kidney disease (DKD), but prospective studies are scarce. Therefore, we conducted epigenome-wide association studies (EWASs) on early- and late-stage DKD progression using DNA methylation data obtained by analysing baseline blood samples from participants in the Finnish Diabetic Nephropathy Study type 1 diabetes cohort. Methods We included 403 individuals with normal AER (early-stage progression group) and 372 individuals with severe albuminuria (late-stage progression group), and followed up DKD progression, defined as a decrease in eGFR to

Fields of Study & Subjects

Epigenetics and DNA Methylation Chronic Kidney Disease and Diabetes Genetic Associations and Epidemiology

Publication details

Journal / source
Diabetologia
Publisher
Springer Science and Business Media LLC
Volume
69
Issue
5
Pages
1317–1336
Publication date
22 January 2026
Language
EN