From pancreas and islet resources to diabetes insights

Diabetologia 2026 Open access

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Authors: Sing-Young Chen, Christiana Lekka, Jonas Lemvig, Xiaoyan Yi, Miriam Cnop, Piero Marchetti, Lorella Marselli, Jianguo Xia, Jesper G S Madsen, Teresa Rodriguez-Calvo, Sarah J. Richardson, James D. Johnson
+1 more Patrick Edward MacDonald
DOI: 10.1007/s00125-026-06731-4
Cited by: 1
References: 5

Abstract

Pancreatic islets of Langerhans are central to the pathogenesis of all major forms of diabetes. The ability to study human islets ex vivo has advanced our understanding of diabetes and aided in the development of novel therapeutics. However, for decades, very few laboratories had access to this critical resource and experiments on human islets were typically underpowered. More recently, multiple consortia around the world have started to enable islet biology at scale, enriching our understanding of the intra-individual variability of islet function and disease mechanisms. This article reviews and compares existing large-scale human islet tissue and data resources, offering suggestions for their improvement and for developing new resources.

Fields of Study & Subjects

Pancreatic function and diabetes Diabetes and associated disorders Aldose Reductase and Taurine

Publication details

Journal / source
Diabetologia
Publisher
Springer Science and Business Media LLC
Volume
69
Issue
7
Pages
1741–1758
Publication date
1 May 2026
Language
EN