Effect of somatostatin receptor 2 antagonism on glucagon counterregulation during a hyperinsulinaemic euglycaemic–hypoglycaemic glucose clamp in adult men and women with long-standing type 1 diabetes: a randomised crossover phase 1 study

Diabetologia 2026 Open access

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Authors: Alexander Abitbol, Michael Charles Riddell, Susan Peers, Eric Simonson, Mark Evans, Filip K. Knop, Richard Liggins
DOI: 10.1007/s00125-026-06748-9
Cited by: 1
References: 49

Abstract

AIMS/HYPOTHESIS: The aim of this study was to determine the effect of a novel somatostatin receptor 2 (SSTR2) antagonist, ZT-01, on impaired glucagon counterregulation in hypoglycaemia and its safety in adults with type 1 diabetes. METHODS: 42.1-74.9 mmol/mol and C-peptide

Fields of Study & Subjects

Diabetes Management and Research Diabetes Treatment and Management Pancreatic function and diabetes

Publication details

Journal / source
Diabetologia
Publisher
Springer Science and Business Media LLC
Volume
69
Issue
8
Pages
2143–2154
Publication date
21 May 2026
Language
EN