Lip Flip Revisited: Clinical Outcomes and Neuromodulatory Basis of Upper Lip Eversion

Aesthetic Plastic Surgery 2026 Open access

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Authors: Marcelo Germani, Victor R. M. Munoz-Lora, Pietra Roschel, Sebastian Cotofana
DOI: 10.1007/s00266-026-05727-0
Cited by: 1
References: 6

Abstract

The lip flip procedure, involving intramuscular injection of botulinum toxin into the orbicularis oris, has gained popularity as a minimally invasive alternative to lip fillers. In this prospective study, 17 women underwent standardized upper lip neuromodulation with 4U of onabotulinumtoxinA. Objective evaluation by stereophotogrammetry demonstrated a modest but significant increase in upper lip height at 15 days (p=0.011), with no change in lip volume. Patient-reported outcomes showed significant improvement in perioral appraisal scores (p

Fields of Study & Subjects

Facial Rejuvenation and Surgery Techniques Botulinum Toxin and Related Neurological Disorders Facial Nerve Paralysis Treatment and Research

Publication details

Journal / source
Aesthetic Plastic Surgery
Publisher
Springer Science and Business Media LLC
Volume
50
Issue
11
Pages
4437–4440
Publication date
31 March 2026
Language
EN