Elevated IGF1R and abnormal methylated IGF1R in immune thrombocytopenia

Annals of Hematology 2026 Open access

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Authors: Xiaojuan Zhu, Na Gao, Xiaoyan Li, Ting Yuan, Yanxia Liu, Qingmin Yao, Feng Zhang, Ningning Shan
DOI: 10.1007/s00277-026-06765-z
Cited by: 0
References: 46

Abstract

To investigate possible role of IGF1R/PI3K/Akt/mTOR signal pathway related genes in the pathogenesis of ITP. Akt/mTOR Total Protein 11-plex Magnetic Bead Kit was used for measurement of related genes of IGF1R/PI3K/Akt/mTOR signal pathway in ITP patients and healthy controls. Genome-wide patterns of DNA methylation and gene expression with IGF1R/PI3K/Akt/mTOR signal pathway were determined in ITP and controls respectively. Elevated protein levels of IGF1R was found in ITP patients compared to healthy controls [Median Fluorescence Intensity (inter-quartile range, IQR), 2551.0 (941.1-4213.0) vs 786.50(276.0-2555.0), P

Fields of Study & Subjects

Platelet Disorders and Treatments Heparin-Induced Thrombocytopenia and Thrombosis Immunodeficiency and Autoimmune Disorders

Publication details

Journal / source
Annals of Hematology
Volume
105
Issue
1
Pages
34–34
Publication date
20 January 2026
Language
EN