Motor fatigue and fatigability in early multiple sclerosis patients: an analysis of clinical, radiological and psychological underpinnings

Neurological Sciences 2026 Open access

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Authors: Matteo Betti, C. Masciulli, I. Addazio, C. Ballerini, R. Bonacchi, A. Caporali, F. Chiappetta, E. De Meo, C. Fabbiani, F. Gerli, U. Kihlbom, C. Niccolai
+9 more G. Pasquini, L. Pastò, V. Penati, K. Scholin Bywall, Jennifer Viberg Johansson, E. Fainardi, S. Martin, E. Portaccio, MP. Amato
DOI: 10.1007/s10072-026-08988-4
Cited by: 2
References: 39

Abstract

BACKGROUND: While fatigue is highly reported in newly diagnosed people with Multiple Sclerosis (pwMS) and motor fatigability is reported in about 20% of non-disabled patients, relationship among them in early MS has been less studied. OBJECTIVE: To evaluate correlations between fatigue and motor fatigability in early pwMS, and their clinical, radiological, psychological underpinnings. METHODS: Relapsing pwMS aged 18-65 years, Expanded Disability Status Scale (EDSS) score

Fields of Study & Subjects

Multiple Sclerosis Research Studies Amyotrophic Lateral Sclerosis Research Peripheral Neuropathies and Disorders

Publication details

Journal / source
Neurological Sciences
Publisher
Springer Science and Business Media LLC
Volume
47
Issue
4
Publication date
27 March 2026
Language
EN