HBV reprograms the tumor microenvironment in hepatocellular carcinoma: mechanisms and therapeutic implications
Abstract
Hepatitis B virus (HBV) infection is an important worldwide health issue and attribute to hepatocellular carcinoma (HCC) via direct oncogenic and indirect mechanisms. HBV reprograms the tumor microenvironment (TME) through immunosuppression, metabolic adaptation, and stromal remodel, allowing tumor promotion and immune evasion. This review examines HBV-induced TME changes, including epigenetic dysregulation, immune cell dysfunction, and fibrosis, as well as new therapeutic options including immune checkpoint blockade, adoptive cell therapy, and metabolic targeting to improve outcomes in HBV-related HCC.
Fields of Study & Subjects
Cancer
Hypoxia
and Metabolism
Hepatocellular Carcinoma Treatment and Prognosis
Hepatitis B Virus Studies
Publication details
- Journal / source
- Clinical and Experimental Medicine
- Publisher
- Springer Science and Business Media LLC
- Volume
- 26
- Issue
- 1
- Pages
- 148–148
- Publication date
- 11 February 2026
- Language
- EN