Smart nanoparticle delivery systems for curcumin: a targeted strategy to enhance anticancer efficacy and bioavailability

Journal of Materials Science Materials in Medicine 2026 Open access

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Authors: Yang Fu, Yuanxin Ge, Shixiong Yi, Qifeng Peng, Heng Jiang, Jie Zhou
DOI: 10.1007/s10856-026-07012-7
Cited by: 17
References: 338

Abstract

Curcumin, a natural polyphenol derived from Curcuma longa, exhibits potent multimodal anticancer activity by modulating critical oncogenic pathways (e.g., NF-κB, STAT3, PI3K/Akt/mTOR), inducing apoptosis, suppressing angiogenesis, and reversing multidrug resistance (MDR). However, its clinical translation is severely hindered by poor aqueous solubility, rapid metabolism, and negligible oral bioavailability (typically

Fields of Study & Subjects

Curcumin's Biomedical Applications Magnolia and Illicium research Nanoparticle-Based Drug Delivery

Publication details

Journal / source
Journal of Materials Science Materials in Medicine
Publisher
Springer Science and Business Media LLC
Volume
37
Issue
1
Pages
38–38
Publication date
9 February 2026
Language
EN