Enhancing the osteogenic potential of 3D-printed polycaprolactone/hydroxyapatite composite scaffolds via in-situ ZIF-8 surface modification

Journal of Materials Science Materials in Medicine 2026 Open access

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Authors: Saba Moslemi, Ghasem Dini, Fatemeh Ejeian, Aliakbar Najafinezhad, Sayede Tayebe Mousavi Mourkani
DOI: 10.1007/s10856-026-07029-y
Cited by: 1
References: 71

Abstract

Bone defects remain a major clinical challenge, necessitating advanced scaffolds that combine suitable mechanics, bioactivity, and osteoinductive cues for effective regeneration. This study developed 3D-printed polycaprolactone/hydroxyapatite (PCL/HA) composite scaffolds via fused deposition modeling and enhanced their surface with in-situ zeolitic imidazolate framework-8 (ZIF-8) modification to promote osteogenic performance. Hydrothermally synthesized HA nanoparticles exhibited high crystallinity,

Fields of Study & Subjects

Bone Tissue Engineering Materials Calcium Carbonate Crystallization and Inhibition 3D Printing in Biomedical Research

Publication details

Journal / source
Journal of Materials Science Materials in Medicine
Publisher
Springer Science and Business Media LLC
Volume
37
Issue
1
Publication date
13 April 2026
Language
EN