Assessment of phenprocoumon stability and excipient compatibility using thermoanalytical techniques and FT-IR spectroscopy
Abstract
Abstract Phenprocoumon, a widely used anticoagulant in Europe, was assessed for solid-state compatibility with common tablet excipients by FT-IR over time and by thermogravimetric analysis. The excipients investigated included starch, hydroxypropyl methylcellulose, magnesium stearate, lactose, mannitol, talc, silicon dioxide, and polyvinylpyrrolidone, as they are frequently employed in tablet manufacturing as fillers, binders, disintegrants, or lubricants. All excipients proved compatible except magnesium stearate, which showed clear signs of interaction in both FT-IR and thermal analysis, indicating a specific incompatibility that requires caution in formulation. Such compatibility studies are essential in pharmaceutical development, as drug–excipient interactions may compromise stability, bioavailability, and overall therapeutic efficacy.
Fields of Study & Subjects
Drug Solubulity and Delivery Systems
Microencapsulation and Drying Processes
Inhalation and Respiratory Drug Delivery
Publication details
- Journal / source
- Journal of Thermal Analysis and Calorimetry
- Publisher
- Springer Science and Business Media LLC
- Volume
- 151
- Issue
- 20
- Pages
- 16825-16838
- Publication date
- 22 June 2026
- Language
- EN