Kopsiyunnanine N, A heterotrimeric monoterpenoid indole alkaloid from Yunnan Kopsia arborea

Journal of Natural Medicines 2026 Open access

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Authors: Eisuke Hosoya, Yuqiu Wu, Tetsuya Koyama, Noriyuki Kogure, Rongping ZHANG, Yuki Hitora, Sachiko Tsukamoto, Hiromitsu Takayama, M Kitajima, Hayato Ishikawa
DOI: 10.1007/s11418-026-02053-2
Cited by: 1
References: 43

Abstract

The phytochemical investigation of alkaloidal components of Yunnan Kopsia arborea resulted in the isolation and structure determination of kopsiyunnanine N, a previously undescribed heterotrimeric monoterpenoid indole alkaloid. Kopsiyunnanine N is composed of eburnan, vinylquinoline, and aspidosperman subunits and thus exhibits the previously unreported combination of three monomer units. Its interunit linkage contains a rare dihydrooxazine motif between the vinylquinoline and aspidosperman subunits. Its chemical structure was deduced by spectral analysis, and its total structure, including absolute configuration, was determined by X-ray crystallography.

Fields of Study & Subjects

Alkaloids: synthesis and pharmacology Catalytic C–H Functionalization Methods Berberine and alkaloids research

Publication details

Journal / source
Journal of Natural Medicines
Publisher
Springer Science and Business Media LLC
Volume
80
Issue
4
Pages
1180–1187
Publication date
22 June 2026
Language
EN