New Insights from the Expression of the Mismatch Repair System in Pituitary Neuroendocrine Tumors

Endocrine Pathology 2026 Open access

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Authors: Francesca Carbonara, Francesca Gianno, Tiziana Feola, Francesco Mancinelli, Dario De Alcubierre, Mariana Ayumi Moroni, Eleonora Lucantonio, Antonietta Arcella, Alba Di Pardo, Roberta Morace, A. Isidori, Stefano Gambardella
+2 more Vincenzo Esposito, Jaffrain-Rea Marie-Lise
DOI: 10.1007/s12022-025-09896-7
Cited by: 4
References: 57

Abstract

Although defects in the mismatch repair (MMR) system have been occasionally reported in aggressive/metastatic pituitary neuroendocrine tumors (PitNETs), the potential role of MMR dysregulation in pituitary tumorigenesis is largely unknown. This study aimed to evaluate the expression of the four key MMR components in a large series of PitNETs. MMR gene expression was studied by RT-qPCR in 127 tumors (54 PIT1, 51 SF1, 22 TPIT), and semi-quantitative immunohistochemistry (score 0-12) in selected cases (n=46). MSH2/6 and MLH1 promoters methylation was studied in 96 tumors. Except for MLH1, tumor lineage of origin was the most significant factor influencing MMR transcripts (P=0.005,

Fields of Study & Subjects

Pituitary Gland Disorders and Treatments Growth Hormone and Insulin-like Growth Factors Hypothalamic control of reproductive hormones

Publication details

Journal / source
Endocrine Pathology
Publisher
Springer Science and Business Media LLC
Volume
37
Issue
1
Pages
2–2
Publication date
2 January 2026
Language
EN