Inherited cancer syndromes in adult oncology: a referral guide based on malignant tumor and polyp features

BACKGROUND: Due to the challenges of identifying patients with hereditary cancer predispositions in oncology practice, we propose a comprehensive and practical tool intended for oncologists managing adult patients with malignant solid tumors and/or gastrointestinal polyps. METHODS: This tool was developed based on a comprehensive review of international guidelines, GeneReviews, and recent literature. Key criteria for genetic referral were compiled and organized by organ site and tumor subtype. RESULTS: The resulting resource includes a primary reference table for genetic referral, a polyposis-specific table, two visual summary figures and curated lists of associated genes and syndromes to streamline the clinical decision-making process. CONCLUSIONS: This comprehensive tool aims to support oncologists in the timely identification of patients eligible for genetic counseling, thereby enhancing therapeutic decisions and improving familial risk assessment.