Temporal changes in first-phase ejection fraction during evolution of heart failure with preserved ejection fraction and afterload-induced heart failure in mice
Abstract
The interplay between systolic and diastolic dysfunction in heart failure with preserved ejection fraction (HFpEF) progression is unclear. First-phase ejection fraction (EF1), a sensitive marker of early systolic function, aids in assessing systolic-diastolic relationships in human hypertension and aortic stenosis. This study examines temporal changes in these relationships in mouse models of HFpEF and elevated afterload. Mouse models of abdominal aortic banding (AAB) and HFpEF (induced by hypertension and high fat feeding) underwent comprehensive serial echocardiography. In AAB, EF1 significantly decreased at week 1 post-surgery (18.8 ± 1.2 vs 24.3 ± 0.8%, p
Fields of Study & Subjects
Cardiovascular Function and Risk Factors
Cardiac Fibrosis and Remodeling
Cardiovascular Disease and Adiposity
Publication details
- Journal / source
- Journal of Physiology and Biochemistry
- Publisher
- Springer Science and Business Media LLC
- Volume
- 82
- Issue
- 1
- Pages
- 7–7
- Publication date
- 4 February 2026
- Language
- EN
- Document type
- Book chapter