Monoterpene indole alkaloids from the aerial parts of Ophiorrhiza brevidentata and their immunological activities

Natural Products and Bioprospecting 2026 Open access

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Authors: Fan Xu, Zheng-Hui Li, Meng-Lin Feng, Jiayu Jin, Bao‐Bao Shi, Ji‐Kai Liu
DOI: 10.1007/s13659-025-00575-y
Cited by: 0
References: 33

Abstract

Abstract Phytochemical study of the EtOAc extract of Ophiorrhiza brevidentata resulted in the discovery of 10 new monoterpene indole alkaloids ( 1–10 ), along with 13 known compounds ( 11 − 23 ). Compound 1 possess an unprecedented skeleton consisting of fused 6/5/6/7/6 polycyclic systems. The structural characterization of these compounds was achieved using Nuclear Magnetic Resonance, Mass Spectrometry and Quantum Chemical Calculations. Compounds 3–5 and 9 exhibited strong inhibition on lipopolysaccharide-induced B cell proliferation with IC 50 values ranging from 3.6–9.1 µM with excellent selectivity indices (SI > 10). Graphical abstract

Fields of Study & Subjects

Phytochemistry and Biological Activities Synthesis and bioactivity of alkaloids Alkaloids: synthesis and pharmacology

Publication details

Journal / source
Natural Products and Bioprospecting
Volume
16
Issue
1
Pages
20–20
Publication date
11 January 2026
Language
EN