Three new 14-noreudesmane-type sesquiterpenoids from the roots of Hippophae rhamnoides

Abstract Hippophae rhamnoides L. (Elaeagnaceae), commonly known as sea buckthorn, is a medicinal plant valued for its diverse bioactive constituents and broad therapeutic potential. Phytochemical investigation of its roots led to the isolation of three new 14-noreudesmane-type sesquiterpenoids ( 1 – 3 ), together with sixteen known compounds ( 4 – 19 ). Their structures and absolute configurations were determined using comprehensive spectroscopic analyses and quantum chemical computations of electronic circular dichroism (ECD) spectra and 13 C NMR shifts. Three new sesquiterpenoids ( 1 – 3 ) were tested for their antioxidant, anti-inflammatory, antibacterial, and α -glucosidase inhibitory activities. Unfortunately, none exhibited significant activity under the tested conditions. Among the isolated known compounds, all those displaying α -glucosidase inhibitory and antibacterial activities are pentacyclic triterpenoids. Hippophamide ( 17 ) showed significant DPPH and ABTS radical-scavenging activity. These results enriched the chemical profile of H. rhamnoides roots. Graphical Abstract