Polydeoxyribonucleotide (PDRN) in Dentistry: Narrative Review for Mechanisms and Emerging Clinical Applications

BACKGROUND: Polydeoxyribonucleotide (PDRN) has emerged as a promising and cost-effective biological agent in regenerative medicine due to its anti-inflammatory, angiogenic, and tissue-regenerative properties. METHODS: A receptor and nucleotide provision via the salvage pathway, and summarizes its biological roles in dental regeneration together with current preclinical and clinical evidence. RESULTS: In dentistry, PDRN has been shown to enhance osteogenesis and vascularization when used with bone graft scaffolds, to exert anti-inflammatory and chondroprotective effects in temporomandibular joint disorders, and to modulate pain pathways in neuropathic conditions. It has also demonstrated adjunctive benefits in managing inflammatory oral diseases such as peri-implantitis and medication-related osteonecrosis of the jaw, where its dual regenerative and anti-inflammatory actions support both soft- and hard-tissue healing. CONCLUSION: Although these findings highlight broad therapeutic potential, current evidence remains limited. Most reports derive from preclinical experiments or small-scale clinical studies, and well-designed randomized controlled trials are needed to validate efficacy of PDRN and define its optimal clinical indications in evidence-based dental protocols.