Dementia in Progressive Supranuclear Palsy: A Narrative Review

Neurology and Therapy 2026 Open access

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Authors: Kathleen S. Moore, Yara S. Stipho, Nicki Niemann, Holly A. Shill, Justine Chan, Crystal J. Abrego, Danielle E. Eagan, Boris Decourt, Marwan N. Sabbagh
DOI: 10.1007/s40120-025-00884-x
Cited by: 1
References: 108

Abstract

Progressive supranuclear palsy (PSP) is an adult-onset neurodegenerative disorder characterized by postural instability, ocular motor dysfunction, akinesia, and cognitive impairment. The accumulation of tau protein disrupts microtubule dynamics and axonal transport, leading to neurodegeneration in subcortical structures such as the basal ganglia and brainstem. These effects result in the clinical features of motor dysfunction and cognitive impairment associated with PSP. Dementia in patients with PSP is common but may be difficult to diagnose. This narrative review describes the cognitive decline and dementia associated with PSP. The pathological hallmarks of PSP, clinical features, and diagnostic criteria are also discussed to provide additional context for the diagnosis of PSP dementia.

Fields of Study & Subjects

Parkinson's Disease Mechanisms and Treatments Genetic Neurodegenerative Diseases Alzheimer's disease research and treatments

Publication details

Journal / source
Neurology and Therapy
Publisher
Springer Science and Business Media LLC
Volume
15
Issue
2
Pages
479–496
Publication date
19 January 2026
Language
EN