A High-Performance Computing Portal Applied to 3D Electron Microscopy

Abstract The continued expansion in size and resolution of volumetric datasets generated by electron microscopy (3DEM) is making high-performance computing (HPC) an essential component. HPC provides the scalable, parallelized infrastructure required to process and analyze these increasingly large datasets. The Texas Advanced Computing Center’s (TACC) Core Experience Portal (CEP) is a science gateway specialized for leveraging HPC. The CEP can be adapted into customized versions based on a research community’s needs. Here we have constructed 3dem.org as a gateway for the community exploring volumetric data generated by electron microscopy (3DEM). This gateway provides the 3DEM community with user-friendly browser-based access to raw and processed datasets including both private and shared data, image processing tools for alignment and segmentation, and simulation and analysis environments. All this is linked to the underlying HPC environment at TACC with the ability to connect to other data storage and compute systems. 3dem.org bridges advanced electron microscopy with HPC, providing the research community with scalable, accessible infrastructure for discovery.