The Interaction Between Triglyceride–Glucose Index and Visceral Adiposity in Arterial Stiffness

Abstract Background Arterial stiffness is a critical determinant of cardiovascular risk and is influenced by various metabolic factors. The triglyceride-glucose (TyG) index, an emerging marker of insulin resistance, and visceral adiposity are both associated with arterial stiffness. However, the interaction between TyG index and visceral adiposity in relation to arterial stiffness has not been thoroughly explored. Methods A total of 761 participants underwent health examinations, including measurements of fasting blood glucose, lipid profiles, visceral fat area (VFA), and arterial stiffness assessed by brachial-ankle pulse wave velocity (baPWV). Participants were stratified by TyG index and VFA. Logistics regression and interaction analyses were conducted to assess the combined effect of TyG and VFA on arterial stiffness. Results Both the high TyG index and high VFA were independently associated with arterial stiffness(OR, 3.786, 95% CI 2.383, 6.014, p