Synthesis and characterization of some metal complexes of tetracycline, theophylline and cimetidine

Abstract Metal complexes of Tetracycline, Cimetidine, and Theophylline were prepared by the direct reaction of the respective ligands with metal salts namely copper (I) bromide, cobalt carbonate, and vanadyl sulfate. This thesis contains detailed reports on synthesis and characterization of copper, cobalt and vanadium complexes of tetracycline, theophylline and cimetidine. The complexes were synthesized by direct mixing of the metal salt dissolved in water (solvent) and corresponding ligands dissolved also in water (solvent). The complexes were characterized by Ultraviolet spectrophotometer (UV-Vis), FTIR spectrometer and solubility. Metal complex with formula of M-L x [where L = Ligands (Tetracycline, Cimetidine, and Theophylline) and M = metal ion (Co, VO and Cu I , x = coordination number of the ligands to the central atom (M)] were obtained. Some ligands gave crystalline complexes as it bonds to the central metal (cobalt) and others were powdery as it bonds to the central metal (vanadium & copper).