Chalcones and flavonoids: New perspectives in the modulation of Trypanosoma brucei metacaspase-2

Archives of Biochemistry and Biophysics 2026 Open access

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Authors: Laura Helena Araujo, Mariana Nascimento Romero Trujilho, Estela Mariana Guimarães Lourenço, Ane Caroline Moreira Duarte, João Pedro Martins Silva Costa, María A. Juliano, Wagner Alves de Souza Júdice, Dênis Pires de Lima, Tarsis Ferreira Gesteira, Maurício F.M. Machado
DOI: 10.1016/j.abb.2026.110881
Cited by: 1
References: 48

Abstract

values. Mechanistic studies identified competitive inhibition for EM-1A, EM-1C, and EM-F12C, while EM-1B exhibited non-competitive inhibition. These findings demonstrate chalcone and flavonoid derivatives as potential anti-AHT agents, effectively inhibiting T. brucei metacaspase-2 at micromolar concentrations. Further research is essential to validate their efficacy and safety for therapeutic use.

Fields of Study & Subjects

Trypanosoma species research and implications Research on Leishmaniasis Studies Synthesis and biological activity

Publication details

Journal / source
Archives of Biochemistry and Biophysics
Publisher
Elsevier BV
Volume
782
Pages
110881–110881
Publication date
28 May 2026
Language
EN