Heat stress therapies for head and neck squamous cell carcinoma: Bibliometrics retrospective view

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer globally, with a 5-year survival rate of approximately 46%. Although surgery, radiotherapy, and chemotherapy effectively treat HNSCC, they often cause severe side effects, including mucositis, salivary gland damage, osteonecrosis of the jaw, and other persistent adverse events. In contrast, heat stress-based therapies provide a precise, minimally invasive, and effective alternative. This study aimed to perform an in-depth bibliometric analysis of heat stress-based therapies for HNSCC over the past three decades, with a focus on identifying key trends, innovations, and future challenges, particularly in integrating nanotechnology with molecular therapies. Major research areas include heat shock protein (HSP) metastatic phenotypes, functions, and mechanisms; innovative detection methods and research tools; emerging therapies and pharmaceutical developments; and nanomaterials combined with photothermal therapy for HNSCC treatment. The findings of this study highlight HSPs and nanomaterials as hotspot areas of recent investigation. Additional exploration was done regarding novel detection methods and treatment strategies, especially in the context of precision medicine and minimally invasive approaches. This study offers valuable insights into future HNSCC treatment directions and essential guidance for researchers and clinicians in the field.