Exploring the Use of Boron Neutron Capture Therapy for Recurrent Breast Cancer and Brain Metastases: A Case Series

Advances in Radiation Oncology 2026 Open access

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Authors: Hong Liao, Yi-Wei Chen, Chen-Hsi Hsieh, Ta-Chung Chao, Ko-Han Lin, Jinn‐Jer Peir, Fong‐In Chou, Pin‐I Huang
DOI: 10.1016/j.adro.2026.101998
Cited by: 1
References: 19

Abstract

Boron neutron capture therapy (BNCT) is a biologically guided form of high-linear energy transfer (LET) radiation that combines molecular targeting with precise particle irradiation. It relies on the preferential accumulation of the nonradioactive isotope ¹⁰B within tumor cells, followed by exposure to low-energy neutrons. The neutron capture reaction yields short-range α particles and lithium nuclei that release their energy within a few micrometers—the approximate diameter of a single cell—producing lethal double-strand DNA breaks largely confined to boron-loaded cells.

Fields of Study & Subjects

Boron Compounds in Chemistry Radiopharmaceutical Chemistry and Applications Organoboron and organosilicon chemistry

Publication details

Journal / source
Advances in Radiation Oncology
Publisher
Elsevier BV
Volume
11
Issue
5
Pages
101998–101998
Publication date
16 January 2026
Language
EN