Nodular Meningeal Recurrence After Laser Interstitial Thermal Therapy for Brain Metastasis: Diagnostic Challenges and Role of Reirradiation With Preoperative Fractionated Stereotactic Radiation Therapy

Advances in Radiation Oncology 2026 Open access

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Authors: Marshall Harrell, Tuğçe Kütük, Alexander Crum, Natalie M. Clark, Joshua Palmer, Raju R. Raval, Sasha J. Beyer, Simeng Zhu, J.C. Grecula, Dukagjin M. Blakaj, James Bradley Elder, Raj Singh
DOI: 10.1016/j.adro.2026.102046
Cited by: 1
References: 17

Abstract

Nodular meningeal disease (NMD) is a clinically significant recurrence pattern characterized by discrete meningeal tumor involvement, most commonly arising along the dura, and is strongly associated with neurosurgical resection followed by adjuvant stereotactic radiosurgery (SRS) [1]. Historically, whole-brain radiotherapy (WBRT) was the standard postoperative treatment, providing comprehensive coverage of microscopic disease beyond the resection cavity [2]. However, concerns over delayed neurocognitive toxicity have driven a shift away from WBRT toward focal approaches such as SRS and fractionated stereotactic radiotherapy (FSRT) [3].

Fields of Study & Subjects

Brain Metastases and Treatment Meningioma and schwannoma management Glioma Diagnosis and Treatment

Publication details

Journal / source
Advances in Radiation Oncology
Publisher
Elsevier BV
Volume
11
Issue
7
Pages
102046–102046
Publication date
1 April 2026
Language
EN