Accuracy of site versus core laboratory interpretations of right heart catheterization hemodynamics

• Right heart catheterization hemodynamics guide heart failure and pulmonary hypertension care, but the accuracy of the site compared to core laboratory interpretations remains uncertain. • Our findings suggest that site and core laboratory readings of mean pulmonary artery pressure and pulmonary capillary wedge pressure were largely concordant. • Across key hemodynamic thresholds, about 10-13% of interpretations were underestimated, which could influence clinical decision-making, though likely mitigated by the broader clinical context in real-world practice. An accurate interpretation of hemodynamics measured by right heart catheterization (RHC) is crucial for guiding the management of heart failure and pulmonary hypertension. We evaluated the concordance and variability between site-reported and core laboratory-adjudicated interpretations of invasive hemodynamic measurements.