Association between time to target mean arterial pressure and 90-day mortality in septic shock: a post hoc analysis of the OPTPRESS trial

Annals of Intensive Care 2026 Open access

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Authors: Ryuto Yokoyama, Tatsuya Hayasaka, Kenya Yarimizu, Kazuma Yamakawa, Takashi Tagami, Yutaka Umemura, Akira Endo
DOI: 10.1016/j.aicoj.2026.100088
Cited by: 1
References: 31

Abstract

Background: In septic shock resuscitation, maintaining a mean arterial pressure (MAP) of at least 65 mmHg is recommended; however, the clinical relevance of the time required to achieve target MAP remains unclear. We evaluated the association between time to target MAP (TTT-MAP) and clinical outcomes in septic shock. Methods: This post hoc secondary analysis used data from the OPTPRESS randomized controlled trial. TTT-MAP was defined as the time from randomization to first attainment of the randomized-arm lower-bound MAP target (80 mmHg in the high-target arm; 65 mmHg in the low-target arm) and categorized as

Fields of Study & Subjects

Sepsis Diagnosis and Treatment Hemodynamic Monitoring and Therapy Trauma Hemostasis Coagulopathy Resuscitation

Publication details

Journal / source
Annals of Intensive Care
Publisher
Elsevier BV
Volume
16
Pages
100088–100088
Publication date
1 January 2026
Language
EN