Changes in nasal and oral microbiota composition during a 10-day decolonization course with mupirocin and povidone-iodine: A real-world case series

American Journal of Infection Control 2026 Open access

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Authors: Thomas C. Scheier, Tomáš Demeter, Jessica Franz, Branko Duvnjak, Bhavya Chakrakodi, Roger D. Kouyos, Patrick R. Schmidlin, Silvio D. Brugger
DOI: 10.1016/j.ajic.2026.05.015
Cited by: 1
References: 8

Abstract

Microbiota composition influences methicillin-resistant S aureus (MRSA) colonization, yet the contribution of the oral microbiota and the impact of decolonization approaches remain insufficiently explored. In this study, we report microbiota shifts in 3 adults with oral MRSA colonization who underwent decolonization treatment, including povidone-iodine. Relative bacterial abundances fluctuated across oral sites and over time, indicating distinct ecological responses to treatment. These findings improve our understanding of how the oral microbiota may affect MRSA decolonization and highlight the importance of oral microbial dynamics to guide more personalized and effective strategies.

Fields of Study & Subjects

Oral microbiology and periodontitis research Pneumonia and Respiratory Infections Antibiotic Use and Resistance

Publication details

Journal / source
American Journal of Infection Control
Publisher
Elsevier BV
Volume
54
Issue
10
Pages
1114–1116
Publication date
22 May 2026
Language
EN