In women with chronic hypertension, does fetal growth restriction increase progression to maternal preeclampsia?

American Journal of Obstetrics and Gynecology 2026 Open access

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Authors: Laura A. Magee, Christos Chatzakis, Argyro Syngelaki, Ranjit Akolekar, Peter von Dadelszen, Kypros H. Nicolaides
DOI: 10.1016/j.ajog.2026.04.014
Cited by: 1
References: 22

Abstract

BACKGROUND: Among women with chronic hypertension, it is unclear whether uteroplacental dysfunction should be classified as indicating superimposed preeclampsia or be considered a direct complication of chronic hypertension. OBJECTIVE: To evaluate whether fetal growth concerns at a routine fetal ultrasound at 35+0 to 36+6 weeks of gestation were related to progression to preeclampsia. STUDY DESIGN: weeks' gestation. We compared the incidence of preeclampsia and other adverse pregnancy outcomes between cases and propensity score-matched controls; cases had an estimated fetal weight 95th percentile, umbilical artery pulsatility index >95th percentile, or middle cerebral artery pulsatility index

Fields of Study & Subjects

Pregnancy and preeclampsia studies Gestational Diabetes Research and Management Birth Development and Health

Publication details

Journal / source
American Journal of Obstetrics and Gynecology
Publisher
Elsevier BV
Volume
235
Issue
3
Pages
677–685
Publication date
15 April 2026
Language
EN