Younger Liver Transplant Recipients with HCC are Less Likely to Have Cancer Confirmed on Explant Pathology

American Journal of Transplantation 2026 Open access

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Authors: Winnie Gaya Shivega, C. Kristian Enestvedt, Madelaine A. Hack, Pushpa Neppala, Alexandra C. Bolognese, Christopher Connelly, Erin C. Maynard, David Scott, Oren Shaked, David C. Woodland, Willscott E. Naugler
DOI: 10.1016/j.ajt.2025.12.257
Cited by: 0

Abstract

Background: Hepatocellular carcinoma (HCC) is routinely diagnosed by imaging alone prior to liver transplantation (LT). This approach may result in overdiagnosis in the absence of pathologic confirmation pre-LT. This study aimed to identify predictors of discordance between pre-transplant imaging-based, and post-transplant, tissue-based HCC diagnosis in transplant recipients. Methods: Adults LT recipients in the OPTN/SRTR database with pre-transplant HCC diagnosis and available explant pathology results for the years 01/2012-09/2024 were included.

Fields of Study & Subjects

Hepatocellular Carcinoma Treatment and Prognosis Organ Transplantation Techniques and Outcomes Liver Disease Diagnosis and Treatment

Publication details

Journal / source
American Journal of Transplantation
Volume
26
Issue
1
Pages
S121–S122
Publication date
1 January 2026
Language
EN