Black urine
Abstract
A 56-year-old man with a past medical history of stage IV metastatic melanoma with BRAF and TERT mutations presented to the hospital with a diffuse rash, diarrhea and dark-colored urine. These symptoms started three days after immune checkpoint inhibitor therapy with nivolumab and ipilimumab. Nephrology was consulted for new onset of cola-colored urine.
Fields of Study & Subjects
Cancer Immunotherapy and Biomarkers
Methemoglobinemia and Tumor Lysis Syndrome
Renal Diseases and Glomerulopathies
Publication details
- Journal / source
- The American Journal of Medicine
- Volume
- 139
- Issue
- 10
- Pages
- e276–e277
- Publication date
- 4 March 2026
- Language
- EN