Prevalence, risk factors and management of bone complications in Cushing's syndrome across Europe. Data from the European Registry on Cushing's syndrome (ERCUSYN)

Aleksandra Zdrojowy-Wełna; Claudia Amaral; Marta Araujo-Castro; Nienke Ruurdje Biermasz; Marek Bolanowski; Jens Bollerslev; Thierry Brue; Davide Carvalho; Frederic Castinetti; Filippo Ceccato; Justine Cristante; Daniela Dadej; Mario Detomas; Timo Deutschbein; Emanuele Ferrante; Атанаска Еленкова; Joan Gil; Ezio Ghigo; Aleksandra Gilis-Januszewska; Roberta Giordano; Miklos Goth; Cecile Greaud; Yona Greenman; Daniela Guelho; Irena Ilovayskaya; Sonia Kaniuka-Jakubowska; Darko Kastelan; Tomaz Kocjan; Irina V. Komerdus; Michal Krsek; Dominique Maiter; Olga Moros; Katarina Mlekuš Kozamernik; Eleni Papakokkinou; Giuseppe Reimondo; Óskar Ragnarsson; Martin Reincke; Helga Ágústa Sigurjónsdóttir; Christian J. Strasburger; Antoine Tabarin; Miklós Tóth; Greisa Vila; Birute Zilaitiene; Alicia Santos; Susan M. Webb; Elena Valassi

doi:10.1016/j.ando.2026.102490

Prevalence, risk factors and management of bone complications in Cushing's syndrome across Europe. Data from the European Registry on Cushing's syndrome (ERCUSYN)

Annales d Endocrinologie 2026 Open access

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Authors: Aleksandra Zdrojowy-Wełna, Claudia Amaral, Marta Araujo-Castro, Nienke Ruurdje Biermasz, Marek Bolanowski, Jens Bollerslev, Thierry Brue, Davide Carvalho, Frederic Castinetti, Filippo Ceccato, Justine Cristante, Daniela Dadej

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Mario Detomas, Timo Deutschbein, Emanuele Ferrante, Атанаска Еленкова, Joan Gil, Ezio Ghigo, Aleksandra Gilis-Januszewska, Roberta Giordano, Miklos Goth, Cecile Greaud, Yona Greenman, Daniela Guelho, Irena Ilovayskaya, Sonia Kaniuka-Jakubowska, Darko Kastelan, Tomaz Kocjan, Irina V. Komerdus, Michal Krsek, Dominique Maiter, Olga Moros, Katarina Mlekuš Kozamernik, Eleni Papakokkinou, Giuseppe Reimondo, Óskar Ragnarsson, Martin Reincke, Helga Ágústa Sigurjónsdóttir, Christian J. Strasburger, Antoine Tabarin, Miklós Tóth, Greisa Vila, Birute Zilaitiene, Alicia Santos, Susan M. Webb, Elena Valassi

DOI: 10.1016/j.ando.2026.102490

Cited by: 1

References: 50

Abstract

OBJECTIVE: The aim of the study was to investigate bone comorbidities and their management in patients included in the European Register on Cushing's syndrome (ERCUSYN). DESIGN: A retrospective multicentric cohort study and on-line survey. METHODS: We analyzed the prevalence of osteoporosis (OP) and fractures among 1682 patients with Cushing's syndrome (CS), at initial evaluation and during follow-up. All the ERCUSYN partners received a survey addressing bone disease management in CS. RESULTS: Seven hundred and sixty-six patients (45%) had DXA examination at baseline, of whom 157 (21%) presented OP at spine and 103 (13%) at hip. Risk factors for OP were older age (P=0.038) and lower BMI (P=0.022). An X-ray was performed in 492 (29%) patients and fracture was detected in 87 (18%). Risk factors for fractures at baseline were male sex (P

Fields of Study & Subjects

Pituitary Gland Disorders and Treatments Adrenal Hormones and Disorders Bone health and osteoporosis research

Publication details

Journal / source: Annales d Endocrinologie
Publisher: Elsevier BV
Volume: 87
Issue: 1
Pages: 102490–102490
Publication date: 1 February 2026
Language: EN

References 50