LDL-cholesterol calculation methods and their influence on the indications for cholesterol-lowering treatment

Annales d Endocrinologie 2026 Open access

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Authors: Sébastien Magnifico, Charlotte Durand-Maugard, Agnès Boullier, Rachel Desailloud, Antoine Galmiche, Abdallah Al‐Salameh
DOI: 10.1016/j.ando.2026.102560
Cited by: 1
References: 21

Abstract

INTRODUCTION: The Friedewald equation is problematic at high triglyceride or low LDL-c levels. Alternatives, such as the Martin-Hopkins or Sampson-NIH equations, have been proposed. This study aims to compare LDL-c estimates derived from these 3 equations with directly measured LDL-c and to assess whether the choice of equation affects clinical management. METHODS: LDL-c levels calculated on the 3 equations were compared with measured LDL values. Comparisons were stratified by total triglyceride (TG) (0-400mg/dL, 400-800mg/dL and>800mg/dL) and LDL-c levels (below or above 70mg/dL). Random samples were selected from each category (TG 0-400mg/dL, TG 400-800mg/dL and LDL-c

Fields of Study & Subjects

Lipoproteins and Cardiovascular Health Diabetes Cardiovascular Risks and Lipoproteins Cholesterol and Lipid Metabolism

Publication details

Journal / source
Annales d Endocrinologie
Publisher
Elsevier BV
Volume
87
Issue
4
Pages
102560–102560
Publication date
21 April 2026
Language
FR