The Preoperative Role of Right-Sided Heart Function in Primary Graft Dysfunction After Bilateral Lung Transplantation

The Annals of Thoracic Surgery 2026 Open access

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Authors: Michal Schäfer, Joseph C. Heiler, Laura DiChiacchio, Satvik Ramakrishna, Ethan Tumarkin, Bryce Hill, Andrew Scott, Sanjeev M. Raman, Laura Frye, Barbara C. Cahill, Matthew R. Morrell, Hiroshi Kagawa
+3 more Nicolas Contreras, Craig H. Selzman, Matthew L. Goodwin
DOI: 10.1016/j.athoracsur.2026.02.030
Cited by: 0
References: 29

Abstract

BACKGROUND: There are conflicting reports on the role of hyperdynamic right ventricular (RV) function contributing to ischemia-reperfusion injury and the development of primary graft dysfunction (PGD) after lung transplantation (LTx). We evaluated preoperative right atrial (RA) and RV strain in LTx patients and tested their predictive role in development of PGD and overall survival. METHODS: Preoperative echocardiography of patients who underwent bilateral LTx at a single center from 2014 to 2025 was analyzed for RA strain as well as for RV free wall and global longitudinal strain. The presence of PGD grade 3 was defined as a partial pressure of arterial oxygen/fractional inspired oxygen ratio

Fields of Study & Subjects

Transplantation: Methods and Outcomes Organ Transplantation Techniques and Outcomes Pulmonary Hypertension Research and Treatments

Publication details

Journal / source
The Annals of Thoracic Surgery
Volume
122
Issue
2
Pages
474–483
Publication date
7 March 2026
Language
EN