Sympathetic transduction to blood pressure following three days in hypobaric hypoxia: Influence of nocturnal periodic breathing

Autonomic Neuroscience 2026 Open access

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Authors: James P. Fisher, Johanna Roche, Amanda G. Duffy, Abubaker Ibrahim, Rachel Turner, Giovanni Vinetti, Matteo Cesari, Michaël Furian, Ambra Stefani, Hannes Gatterer, Birgit Högl, Christoph Siebenmann
DOI: 10.1016/j.autneu.2026.103386
Cited by: 0
References: 10

Abstract

We investigated whether three days of hypoxic exposure in a hypobaric chamber, and the associated nocturnal periodic breathing (nPB), reduce sympathetic nerve activity (MSNA) transduction to blood pressure (BP). While hypoxia did not affect MSNA transduction to BP, larger drops in BP occurred following cardiac cycles without sympathetic bursts, suggesting increased reliance on sympathetic vasoconstrictor support for beat-to-beat BP. Prevention of nPB by inspiratory carbon dioxide administration did not affect MSNA transduction to BP in hypoxia.

Fields of Study & Subjects

High Altitude and Hypoxia Neuroscience of respiration and sleep Heart Rate Variability and Autonomic Control

Publication details

Journal / source
Autonomic Neuroscience
Volume
264
Pages
103386–103386
Publication date
13 January 2026
Language
EN