Yeast phosphatidylinositol transfer protein Pdr16 supports azole resistance independently of lipid droplets

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2026 Open access

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Authors: Lucia Pokorná, Dana Tahotná, Rebeka Rusnáková, Zuzana Pevalová, Dominik Šťastný, Peter Griač
DOI: 10.1016/j.bbalip.2026.159721
Cited by: 0
References: 16

Abstract

• Pdr16p is a potential target for preventing the development of azole resistance in fungi. • The molecular mechanism by which Pdr16p supports azole resistance remains unclear. • Pdr16p predominantly localizes to lipid droplets (LDs) in yeast cells. • Neither the presence of LDs nor the localization of Pdr16p to LDs contributes to azole resistance in yeast. • Pdr16p may play a role in adjusting ergosterol biosynthesis in response to azole treatment.

Fields of Study & Subjects

Antifungal resistance and susceptibility Fungal and yeast genetics research Lipid metabolism and biosynthesis

Publication details

Journal / source
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Volume
1871
Issue
2
Pages
159721–159721
Publication date
11 January 2026
Language
EN