Potential role of circ_WHSC1 and miR-145-5p in breast cancer promotion

Biochemistry and Biophysics Reports 2026 Open access

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Authors: Maryam Abtin, Asghar Hosseinzadeh, Nahid Nafisi, Ramesh Omranipour, Leyla Sahebi, Mohsen Ahmadi, Soudeh Ghafouri‐Fard, Abbas Shakoori
DOI: 10.1016/j.bbrep.2026.102472
Cited by: 1
References: 30

Abstract

This study aims to investigate the potential interplay between circ_WHSC1 and miR-145-5p in breast cancer pathogenesis using in silico tools, assess their clinical relevance, and evaluate the diagnostic utility of circ_WHSC1 in clinical samples as a biomarker for breast cancer. This multi-component study employed a combination of bioinformatic analyses and laboratory validation. First, in silico tools were used to investigate miR-145-5p and circ_WHSC1 using public databases. Subsequently, their expression, correlation, and clinical relevance were experimentally assessed in a cohort of breast cancer patients. Circ_WHSC1 level was significantly higher in breast tumor compared with patient-matched adjacent normal tissues (4.17-fold change, p-value

Fields of Study & Subjects

Connective Tissue Growth Factor Research Circular RNAs in diseases Hippo pathway signaling and YAP/TAZ

Publication details

Journal / source
Biochemistry and Biophysics Reports
Publisher
Elsevier BV
Volume
45
Pages
102472–102472
Publication date
30 January 2026
Language
EN