Vaccination modality and injection site influence the immune response and protection against sea lice Lepeophtheirus salmonis infestation in Atlantic salmon (Salmo salar)
Abstract
Sea lice (Lepeophtheirus salmonis) infestations represent a challenge to Atlantic salmon (Salmo salar) aquaculture. We evaluated recombinant peroxinectin-like proteins (LsPxtl-1 and LsPxtl-2) and whole sea lice (WSL) crude proteins as vaccine antigens, administered intraperitoneally (i.p.) or via a combination of i.p./subcutaneous fin-base injection (IP-F). Fish were immunized, boosted, smoltified, and challenged with copepodites, and systemic (plasma) and mucosal (mucus) antibody responses were assessed alongside lice burden. LsPxtl-1 and IP-F vaccines reduced (p
Fields of Study & Subjects
Parasite Biology and Host Interactions
Aquaculture disease management and microbiota
Myxozoan Parasites in Aquatic Species
Publication details
- Journal / source
- Biochemistry and Biophysics Reports
- Volume
- 46
- Pages
- 102573–102573
- Publication date
- 8 April 2026
- Language
- EN