Loss of cystathionine-β-synthase contributes to elevated OXPHOS, a vulnerability in Ara-C-resistant Myeloid Leukemia in Down syndrome

Biochemical Pharmacology 2026 Open access

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Authors: Jenna Thibodeau, Jianlei Zhao, Holly J. Edwards, Lisa Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Kian K. Hershberger, Yongwei Su, Tasnim Arroum, Lucynda Pham, Lauren Pavelich
+13 more Raina Awdish, Jacob LaValley, Austin C. Boucher, Wei Chen, Jing Li, Xun Bao, Maik Hüttemann, Jessica B. Back, Joshua E. Allen, Varun V. Prabhu, John D. Crispino, Jeffrey Warren Taub, Yubin Ge
DOI: 10.1016/j.bcp.2026.117815
Cited by: 0
References: 32

Fields of Study & Subjects

Acute Myeloid Leukemia Research Sulfur Compounds in Biology Retinoids in leukemia and cellular processes

Publication details

Journal / source
Biochemical Pharmacology
Volume
247
Pages
117815–117815
Publication date
14 February 2026
Language
EN