Cellular therapies in systemic Sclerosis: immunopathogenesis-informed precision targeting with CAR-T and CAR-NK approaches
Abstract
Systemic sclerosis (SSc) is a rare, heterogeneous systemic autoimmune rheumatic disease characterized by immune dysregulation, vasculopathy, and excessive fibrosis. SSc is associated with high morbidity and mortality despite current immunosuppressive and anti-fibrotic therapies. Emerging cellular therapies, particularly chimeric antigen receptor (CAR) T-cell and natural killer (NK) cell approaches offer potential for deep immune reset and long-term remission. This review examines the immunobiological rationale for these therapies in SSc and evaluates their early clinical evidence, including comparisons to other autoimmune diseases.
Fields of Study & Subjects
Systemic Sclerosis and Related Diseases
Mesenchymal stem cell research
CAR-T cell therapy research
Publication details
- Journal / source
- Best Practice & Research Clinical Rheumatology
- Publisher
- Elsevier BV
- Volume
- 40
- Issue
- 1
- Pages
- 102139–102139
- Publication date
- 1 March 2026
- Language
- EN