Spatiotemporal acoustic meta-patches for multifactorial wound treatment

Ultrasound patches have demonstrated values in non-invasive diagnostics through echo reception, while their therapeutic potentials are restricted by precisely controlling ultrasound energy and integrating multi-effects. Here, we introduce a spatiotemporal acoustic meta-patch (STAMP) that generates controllable heating, mechanical, and biological effects for synergistic multifactorial wound treatment. The STAMP utilizes acoustic metamaterial composites, including reconfigurable interdigital transducers (IDTs) and acoustic impedance matching layer, to focus and transport ultrasound energy with high spatial precision and efficiency. This patch exhibits multiple therapeutic effects, such as localized heating, ultrasound-enhanced bioactive agent delivery and cell migration. Based on these beneficial effects, we show that STAMP can precisely and spatiotemporally regulate wound microenvironments by modulating temperature, inflammation, and wound closure, providing a proof-of-concept for enhanced multifactorial wound healing. We believe that the reconfigurable and multifunctional acoustic metamaterials-based patch may open new possibilities for direct ultrasound-based therapeutics. A spatiotemporal acoustic meta-patch (STAMP) with multiple functionalities for multifactorial wound management. • A spatiotemporal acoustic meta-patch (STAMP) is engineered for multifactorial wound therapy. • The patch integrates reconfigurable IDTs and an impedance-matching layer for precise ultrasound energy control. • STAMP simultaneously enables localized thermotherapy, enhanced drug delivery, and accelerated cell migration. • Spatiotemporal regulation of wound microenvironment (temperature, inflammation, closure) is demonstrated. • The work pioneers a new paradigm for ultrasound-based bioactive materials beyond diagnostic applications.