Mechanical loading primes MSC-derived exosomes to promote cartilage repair

Bioactive Materials 2026 Open access

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Authors: Zeng Lin, Chao Jia, Hongwei Lu, Lei Zhou, Jie Guo, Borui Jin, Jinjin Wang, Abudula Aji, Peng Luo, Ling Cai, Libo Jiang, Zhenwu Wang
+1 more Xing Wu
DOI: 10.1016/j.bioactmat.2026.06.023
Cited by: 1
References: 38

Abstract

promotes chondrocyte proliferation and migration while suppressing apoptosis, senescence, and extracellular matrix degradation. Together, these findings identify mechanically primed MSC-derived exosomes as a mechanistically informed therapeutic strategy for cartilage repair.

Fields of Study & Subjects

Osteoarthritis Treatment and Mechanisms Extracellular vesicles in disease MicroRNA in disease regulation

Publication details

Journal / source
Bioactive Materials
Publisher
Elsevier BV
Volume
65
Pages
957–967
Publication date
23 June 2026
Language
EN