High oral doses of vitamin B12 in early pregnancy improve B12 status of mother and child irrespective of subsequent supplementation a longitudinal study in B12 insufficient Indian women supplemented with either milk, vitamin pills, or placebo

Sadanand S. Naik; Sergey N. Fedosov; Namita P. Mahalle; Sharwari Narawade; Ebba Nexø; Christian W. Heegaard

doi:10.1016/j.biochi.2026.01.014

High oral doses of vitamin B12 in early pregnancy improve B12 status of mother and child irrespective of subsequent supplementation a longitudinal study in B12 insufficient Indian women supplemented with either milk, vitamin pills, or placebo

Biochimie 2026 Open access

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Authors: Sadanand S. Naik, Sergey N. Fedosov, Namita P. Mahalle, Sharwari Narawade, Ebba Nexø, Christian W. Heegaard

DOI: 10.1016/j.biochi.2026.01.014

Cited by: 0

References: 22

Abstract

B 12 deficiency during pregnancy has been associated with shunted growth, neural tube defects, anemia, and neuro-cognitive disorders. The optimal prevention strategy remains to be found. Here we explore the effect of high doses of oral B 12 in early pregnancy followed by physiological doses of B 12 or placebo. The women (B 12

Fields of Study & Subjects

Folate and B Vitamins Research Porphyrin Metabolism and Disorders Iron Metabolism and Disorders

Publication details

Journal / source: Biochimie
Publication date: 1 January 2026
Language: EN

References 22