Expanding the chemical and therapeutic landscape of 5H-Indeno[1,2-b]pyridin-5-one derivatives: Novel anticancer activity, EGFR inhibition, and modulation of HIF–VEGF and PI3K/AKT/mTOR pathways supported by computational insights

Bioorganic Chemistry 2026

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Authors: Hagar S. El-Hema, Hadeer A. El-Shazly, Mohamed A. Hawata, N. M. Yousif, Modather F. Hussein, Mohamed Said, EsraaA. Aidy, Haitham E. Shehata, Adel A.‐H. Abdel‐Rahman
DOI: 10.1016/j.bioorg.2026.109476
Cited by: 7
References: 73

Fields of Study & Subjects

Cancer Hypoxia and Metabolism Lung Cancer Treatments and Mutations Cytokine Signaling Pathways and Interactions

Publication details

Journal / source
Bioorganic Chemistry
Publisher
Elsevier BV
Volume
170
Pages
109476–109476
Publication date
7 January 2026
Language
EN